Important advance in the fight against skin cancer
Researchers from the Hospital del Mar Medical Research Institute (IMIM), lead by Lluís Espinosa, have identified a new function of the IB protein that is key in the development of squamous-cell...
View ArticleFinding cellular causes of lung-hardening disease
(Medical Xpress)—Idiopathic Pulmonary Fibrosis, or IPF, is an incurable lung disease that, over time, turns healthy lung tissue into inflexible scar tissue – hardening the lungs and eventually causing...
View ArticleSkin's own cells offer hope for new ways to repair wounds, reduce impact of...
Scientists at King's College London have, for the first time, identified the unique properties of two different types of cells, known as fibroblasts, in the skin – one required for hair growth and the...
View ArticleFibroblasts could offer alternative to heart transplants
(Medical Xpress)—Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.
View ArticleExploring 3-D printing to make organs for transplants
Printing whole new organs for transplants sounds like something out of a sci-fi movie, but the real-life budding technology could one day make actual kidneys, livers, hearts and other organs for...
View ArticleInducing insulin resistance: Human iPS cell model offers new look at key...
(Medical Xpress)—Harvard Medical School researchers at Joslin Diabetes Center have created the first induced pluripotent stem cells (iPSCs) that offer a human model of insulin resistance, a key driver...
View ArticleResearchers boost the heart's natural ability to recover after heart attack
Researchers from the UNC School of Medicine have discovered that cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into endothelial cells, which...
View ArticleReprogrammed cells grow into new blood vessels
By transforming human scar cells into blood vessel cells, scientists at Houston Methodist may have discovered a new way to repair damaged tissue. The method, described in an upcoming issue of...
View Article'Alzheimer's in a Dish' model induces skin cells into neurons expressing...
The search for a living laboratory model of human neurons in the grip of Alzheimer's disease (AD)—the so-called "Alzheimer's in a dish"—has a new candidate. In work presented at the ASCB/IFCB meeting...
View ArticleAn unholy alliance—Colon cancer cells in situ co-opt fibroblasts in...
It means cancer "in place" but a carcinoma "in situ" often does not want to keep its place. Standing between a cancer cell in situ and the surrounding tissue of fibroblasts and extracellular matrix is...
View ArticleIn prostate cancer prognosis, telomere length may matter
Like the plastic caps at the end of shoelaces, telomeres protect—in their case—the interior-gene containing parts of chromosomes that carry a cell's instructional material. Cancer cells are known to...
View ArticleA new factor in depression? Brain protein discovery could lead to better...
Low. Down. Less than normal. That's what the word depression means, and what people with depression often feel like. But sometimes, depression can mean too much of something - as new research shows.
View ArticleCancer cell collaborators smooth the way for cancer cells to metastasize
At ASCB 2015, Vanderbilt researchers show how metastasizing tumors use non-cancerous fibroblasts to make a migration highway through surrounding extracellular matrix.
View ArticleResearchers find link between death of tumor-support cells and cancer metastasis
Researchers have discovered that eliminating cells thought to aid tumor growth did not slow or halt the growth of cancer tumors. In fact, when the cancer-associated fibroblasts (CAFs), were eliminated...
View ArticleStudy uncovers genetic elements that drive regeneration
If you trace our evolutionary tree way back to its roots—long before the shedding of gills or the development of opposable thumbs—you will likely find a common ancestor with the amazing ability to...
View ArticleCocoa pod extract deemed effective as antiwrinkle gel
(HealthDay)—Cocoa pod extract (CPE) can be used as an active ingredient of antiwrinkle products, with effects seen after three weeks of application of CPE gel, according to a study published online...
View ArticleAnti-fibrotic peptide shows early promise against interstitial lung disease
The results of preclinical studies by investigators at the Medical University of South Carolina (MUSC) reported in the April 2016 issue of Translational Research suggest that the M10 peptide could help...
View ArticleHow the heart turns into bone
Connective tissue cells in the heart turn into bone-producing cells in response to injury, University of California, Los Angeles scientists report November 17 in Cell Stem Cell. The discovery helps...
View ArticleFibroblasts could provide new target for treatment of rheumatoid arthritis
A study led by researchers at the University of Birmingham reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for...
View ArticleWhy is pancreatic cancer so hard to treat? Stroma provides new clues
Researchers have moved an important step closer to understanding why pancreatic cancer is so hard to treat. With a median survival of only 6 months and a 5-year survival rate of about 8%, patients tend...
View ArticleCancer cells hijack healthy cells to help them spread to other organs
An interaction between two proteins enables cancer cells to use the physical forces of healthy cells to start spreading to other parts of the body.
View ArticleNew protein discovered in aging and cancer
A protein has been found to have a previously unknown role in the ageing of cells, according to an early study by Queen Mary University of London (QMUL). The researchers hope that the findings could...
View ArticleNew understanding of chronic lung inflammatory diseases unfolding
Researchers studying chronic inflammation that can lead to the development of lung diseases such as asthma, pulmonary fibrosis, and cancer, are focusing on the role cytokines play in regulating the...
View ArticleFibrosis reversed when 'don't eat me' signal blocked, study finds
Researchers at the Stanford University School of Medicine have identified a pathway that, when mutated, drives fibrosis in many organs of the body.
View ArticleWhen healthy cells stimulate the migration of tumor cells
Estrogens act as a driving force of both healthy and cancerous mammary cell growth by binding to receptors that include a type named GPER, which is generally located in cell membranes. Recent studies...
View ArticleCancer cells force normal cells to mimic viruses to help tumors spread,...
In a study that could explain why some breast cancers are more aggressive than others, researchers say they now understand how cancer cells force normal cells to act like viruses - allowing tumors to...
View ArticleStudy hints at experimental therapy for heart fibrosis
Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury—describing an experimental...
View ArticleSignal flare – how heart muscle cells protect themselves from viral invaders
The human heart is particularly vulnerable to viruses. That's because cardiac myocytes, the heart muscle cells that give your heart its ability to "beat," have one major weakness – they don't reproduce...
View ArticleMolecular pathway offers treatment targets for pulmonary fibrosis, related...
A study led by investigators at Massachusetts General Hospital (MGH) and University Health Network (UHN) in Toronto has identified a molecular pathway that appears to be critical to the development of...
View ArticleFinding long strands of RNA in skin development and disease
Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called "long non-coding RNAs" or "lncRNAs," help...
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